Research Achievements and Patents:

Development of semi-synthetic methods for anticancer drugs paclitaxel and docetaxel and development of their analogues
Development of side chain precursor manufacturing method for paclitaxel and docetaxel (manufacturing method patent held)
Development of synthesis method for anti-influenza drug Tamiflu (manufacturing method patent held)
Development of a method for synthesizing the active species of the anti-inflammatory drug loxoprofen
Application to optical resolution and synthesis of secondary alcohols using enzymes
Development of various palladium-catalyzed reactions
Development of synthetic reactions that utilize sulfur compounds
Development of a natural product synthesis method that requires multiple steps
The world's first active ingredient combination
The satisfaction rate of the pre-questionnaire reached 98.1%
※According to our company's investigation
Passed safety test
Patent Ingredient

Unleash the Power of Proprietary Patented Pterostilbene Glycoside! Experience the Transformation Power of Type IV Collagen Generation, Revitalizing and Repairing the Basement Membrane With Intensity.

YOSHIMI JAPAN Bevernal Cream: the ultimate solution for your skin concerns. This innovative external composition effectively reduces wrinkles and fine lines while inhibiting melanogenesis, providing radiant and tightened skin within just *4 weeks.

Pterostilbene Glycoside 紫檀芪糖苷(配醣類)


Unlock the Secret of Skin Transformation With YOSHIMI JAPAN Bevernal Cream: Solving Skin Problems at the Root Cause!

Causes of Skin Problems
Wrinkles, pigmentation, and dullness that come with aging and the damaging effects of extended UVB exposure on the skin.
Basement Membrane
Basement membranes are thin layers of a specialized extracellular matrix that form the supporting structure on which epithelial and endothelial cells grow. Basement membranes do not only provide a mechanical support but also influence cellular behavior. The major molecular constituents of basement membranes are Type IV collagen.
Type IV Collagen
Type IV collagen is a type of collagen that is responsible for providing a scaffold for stability and assembly. It is also predominantly found in extracellular basement membranes. It aids in cell adhesion, migration, survival, expansion, and differentiation.

Clinical research has confirmed that the content of Type IV collagen decreases after the age of 35.

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a natural dietary compound and the primary antioxidant component of blueberries. It has increased bioavailability in comparison to other stilbene compounds. The antioxidant activity of pterostilbene has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.
Proptrietary Patented Pterostilbene Glycoside Boosts the Generation of Type IV Collagen
Pterostilbene Glycoside has been clinically proven its ability to boost the generation of type IV collagen in the skin.

This game-changer ingredient exponentially catapults the bioavailability of Pterostilbene to 100,000 times.

Clinical Research

YOSHIMI JAPAN Bevernal Cream has been classified as a ‘Safe Product’ based on the Japanese National Standard test for skin sensitivity.

Test for Primary Skin Irritation & Hypersensitivity
Clinical Research on Fine Line Reduction Around The Eyes
Test Evidence for Hormonal Spots
YOSHIMI JAPAN is a skincare brand supported by CDW Life Science Limited, a biotech research company in Osaka, Japan. Through collaborations with prominent universities in Japan, YOSHIMI JAPAN has actively participated in the development of various biotechnologies. The company has acquired several exclusive patents related to the synthesis technology of Pterostilbene in Japan, Korea and Europe.

Professor Hiroki Hamada

Head of the Department of Life Science, Okayama University
Professor Hiroki Hamada and CDW Life Science Limited are co-owners of the jointly developed patent for Pterostilbene Glycoside.

CDW Life Science Ltd

CDW Life Science Ltd is a biotechnology R&D company headquartered in Osaka, Japan.
The company is a subsidiary of CDW Holding Limited, a main board-listed company in Singapore Stock Exchange, with the stock code SGX:BXE.

In collaboration with universities and research institutes, the company aims to develop the industry by creating the latest health and beauty products in order to realize new organic chemistry.

The company develops patented ingredients for the purposes to advance the industry and cater to the community.

Premium Ingredients
Dianthus Caryophyllus Flower Extracts


Promotes the production and maturation of Type III collagen (also known as baby collagen) in the skin.
Improves skin softness.
Prevent skin marks.
Lactic Acid Bacterium from the Notorious Fukuoka ‘Amaou’ Strawberry


Increases the number of Staphylococcus epidermis on the skin.
Supports the improvement of sensitive and troublesome skin through its prebiotic effects.
Placental Protein


Increases in stratum corneum water content.
Anti-inflammation activities.
Improves of pigmentation.
Suppresses the production of melanin.
Rice Ferment Filtrate (Sake)

100% use of deep ocean water (below 200m) off the coast of Sado.


Rich in minerals and enzymes, which deeply moisturize the skin.
Stimulates the production of various collagen types.
Extracts Derived from the Organic Plants Grown in Kumamoto Prefecture


Ipomoea batatas leaf/stem extract – anti-oxidant & supression of Melanin production.
Canavalia gladiata seed extract - promotes blood circulation.
Mentha piperita (peppermint) leaf extract – anti-bacterial & anti-allergic.
Artemisia princeps leaf extract – anti-inflammation
Natural Scent

Extracts derived from organic plants grown in Kumamoto.

Lavandlula angustifolia (lavender) flower extract
Cymbopogon schoenanthus leaf/stem extract
Rosmarinus officinalis (rosemary) leaf extract
Other Ingredients

Aqua, glycerin, butylene glycol, melissa officinalis extract, vaccinium myrtillus extract, thymus serpyllum extract, prunus domestica extract, actinidia chinenses extract, sodium hyaluronate, dianthus caryophyllus extract, placental protein, soluble collagen, soluble proteoglycen, rice ferment filtrate, gynostemma pentaphyllum extract, porphyra yezoensis extract, citus reticulata extract, vitis vinifera extract, lactobacillus, maltodextrin, bifida ferment lysate,….